Open medical sources

Research library

Search more than 4,000 verified Europe PMC records and read the original English title, abstract, authors, journal and identifiers.

Research corpus

4,000+ records

Systematic review / meta-analysis 2018
Heart and blood vessels

Comparative efficacy of Chinese herbal injections for treating chronic heart failure: a network meta-analysis.

BMC complementary and alternative medicine

Background On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injecti

Systematic review / meta-analysis 2021
Cancer and oncology

Comparison of atezolizumab, durvalumab, pembrolizumab, and nivolumab as first-line treatment in patients with extensive-stage small cell lung cancer: A systematic review and network meta-analysis.

Medicine

Background In recent years, immune checkpoint inhibitors (ICIs) including atezolizumab, durvalumab, pembrolizumab, and nivolumab have reported their efficacy and safety profile in patients with extensive-stage small cell lung cancer (ES-SCLC). However, given t

Systematic review / meta-analysis 2020
Bones, joints and rehabilitation

Correlation between osteoarthritis and monocyte chemotactic protein-1 expression: a meta-analysis.

Journal of orthopaedic surgery and research

Objective We evaluated the association between monocyte chemotactic protein-1 (MCP-1) and osteoarthritis. Methods We searched PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP (Chinese database), and Wan Fang

Systematic review / meta-analysis 2022
General medicine and research

Delayed Admission to the Intensive Care Unit and Mortality of Critically Ill Adults: Systematic Review and Meta-analysis.

BioMed research international

Delayed admission of patients to the intensive care unit (ICU) is increasing worldwide and can be followed by adverse outcomes when critical care treatment is not provided timely. This systematic review and meta-analysis appraised and synthesized the published

Systematic review / meta-analysis 2018
Prevention and public health

Effect of exercise and/or reduced calorie dietary interventions on breast cancer-related endogenous sex hormones in healthy postmenopausal women.

Breast cancer research : BCR

Background Physical inactivity and being overweight are modifiable lifestyle risk factors that consistently have been associated with a higher risk of postmenopausal breast cancer in observational studies. One biologic hypothesis underlying this relationship m

Systematic review / meta-analysis 2021
Heart and blood vessels

Effect of sodium-glucose cotransporter 2 inhibitors on cardiac structure and function in type 2 diabetes mellitus patients with or without chronic heart failure: a meta-analysis.

Cardiovascular diabetology

Background Although the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiovascular events have been reported in patients with type 2 diabetes mellitus (T2DM) with or without heart failure (HF), the impact of SGLT2i on cardiac remodelling

Systematic review / meta-analysis 2019
General medicine and research

Effectiveness, efficiency and adverse effects of using direct or indirect bonding technique in orthodontic patients: a systematic review and meta-analysis.

BMC oral health

Background The direct and indirect bonding techniques are commonly used in orthodontic treatment. The differences of the two techniques deserve evidence-based study. Materials and methods Randomized controlled trials (RCTs), wherein direct and indirect bonding

Systematic review / meta-analysis 2022
Diabetes and metabolism

Effects of SGLT2 inhibitors on haematocrit and haemoglobin levels and the associated cardiorenal benefits in T2DM patients: A meta-analysis.

Journal of cellular and molecular medicine

To explore the effect and magnitude of effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on haematocrit and haemoglobin and the related cardiorenal benefits in patients with type 2 diabetes mellitus (T2DM), PubMed, Web of Science, CENTRAL and EMBASE

Systematic review / meta-analysis 2019
Children's health

Effects of single and combined water, sanitation and hygiene (WASH) interventions on nutritional status of children: a systematic review and meta-analysis.

Italian journal of pediatrics

Background Under nutrition is linked with poor water, sanitation and hygiene (WASH) condition. However, there is conflicting evidence on the effect of WASH on nutritional status of children. This review was, therefore, conducted to estimate the pooled effect o

Systematic review / meta-analysis 2019
Cancer and oncology

Efficacy and safety of HER2 inhibitors in combination with or without pertuzumab for HER2-positive breast cancer: a systematic review and meta-analysis.

BMC cancer

Background Although the dual anti-HER2 therapy, namely, pertuzumab plus trastuzumab and docetaxel, has shown promising results in HER2+ breast cancer patients, whether the dose, efficacy and safety of this treatment differs from those of other pertuzumab-based

Systematic review / meta-analysis 2020
General medicine and research

eHealth in the support of people with mild intellectual disability in daily life: A systematic review.

Journal of applied research in intellectual disabilities : JARID

Background eHealth has recently made rapid progress in care, support and treatment. However, studies on the use of eHealth to support people with a mild intellectual disability in daily life are limited. A systematic review was conducted to provide an overview

Systematic review / meta-analysis 2021
Brain and nervous system

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer's Disease: A Systematic Review.

International journal of environmental research and public health

This review aims to clarify the nature of the link between Alzheimer's disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. W

Systematic review / meta-analysis 2022
Mental health

Fear of cancer recurrence and PSA anxiety in patients with prostate cancer: a systematic review.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Purpose The impact of prostate cancer on the mental wellbeing of patients is increasingly being appreciated. Two important aspects of this include fear of cancer recurrence (FCR) and prostate-specific antigen (PSA) anxiety. However, their prevalence, severity

Systematic review / meta-analysis 2022
Bones, joints and rehabilitation

Horizontal augmentation techniques in the mandible: a systematic review.

International journal of implant dentistry

Purpose Placement of dental implants has evolved to be an advantageous treatment option for rehabilitation of the fully or partially edentulous mandible. In case of extensive horizontal bone resorption, the bone volume needs to be augmented prior to or during

Systematic review / meta-analysis 2022
General medicine and research

Implant-supported removable partial dentures compared to conventional dentures: A systematic review and meta-analysis of quality of life, patient satisfaction, and biomechanical complications.

Clinical and experimental dental research

Objectives The purpose of this systematic review and meta-analysis was to compare implant-supported removable partial dentures (ISRPDs) with distal extension removable partial dentures (DERPDs) in terms of patient-reported outcome measures (PROMs: patients' qu