Asocijacije između rizika od raka želuca i virusne infekcije osim Epstein-Barr virusa: Sistematski pregled i meta-analiza zasnovana na epidemiološkim studijama.
Clinical and translational gastroenterology
Sažetak istraživanja
Uvod Osim Helicobacter pylori i Epstein-Barr virusa, drugi virusi mogu igrati potencijalnu ulogu u karcinogenezi želuca. Ovaj sistematski pregled i meta-analiza provedeni su kako bi se uporedila prevalencija virusa između raka želuca (GC) i bilo koje kontrole.
Metode Sveobuhvatna literatura je pretražena do 25. januara 2019., a pretraga je ažurirana 6. aprila 2020. Studije koje su upoređivale prevalenciju virusa osim Epstein-Barr virusa između GC-a i zdravih ili nemalignih kontrola bile su prihvatljive. Za testove heterogenosti i meta-analize korišten je softver Stata 12.0. U međuvremenu, izvršena je analiza podgrupa, analiza osjetljivosti i procjena pristranosti publikacije gdje je to bilo primjenjivo. Snaga (1-β) je procijenjena softverom PASS 11 za svaku pojedinačnu studiju.
Rezultati Ukupno je uključena 41 prihvatljiva studija koja se tiče 11 vrsta virusa. Prevalencija je bila značajno veća u GC za virus hepatitisa B (odnos šanse [OR] = 1,39, 95% interval pouzdanosti [CI] 1,11-1,75), humani citomegalovirus (OR = 2,25, 95% CI 1,14-4,43), humani papiloma virus = (HPV1, 5 CI9, OR 1,05-2,54), i John Cunningham virus (OR = 2,52, 95% CI 1,26-5,04). U analizama podgrupa HPV-16 infekcija je bila značajno povezana sa GC (OR = 2,42, 95% CI 1,00-5,83). Diskusija Ova studija je pokazala da su virus hepatitisa B, humani citomegalovirus, HPV i John Cunningham virus bili češći u GC. Međutim, uzročna veza između njihove infekcije i rizika od GC ostaje neuvjerljiva i potrebna su daljnja istraživanja.
Prikaži originalni naslov i sažetak na engleskom
Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies.
Introduction Besides Helicobacter pylori and Epstein-Barr virus, other viruses might play potential roles in gastric carcinogenesis. This systematic review and meta-analysis was conducted to compare the prevalence of the viruses between gastric cancer (GC) and any controls.
Methods Comprehensive literature was searched up to January 25, 2019, and search was updated on April 6, 2020. The studies that compared the prevalence of viruses other than Epstein-Barr virus between GC and healthy or nonmalignant controls were eligible. Stata 12.0 software was used for heterogeneity tests and meta-analyses. Meanwhile, subgroup analysis, sensitivity analysis, and publication bias evaluation were performed where applicable. The power (1-β) was estimated by the PASS 11 software for each individual study.
Results A total of 41 eligible studies were included, concerning 11 kinds of viruses. Prevalence were significantly higher in GC for hepatitis B virus (odds ratio [OR] = 1.39, 95% confidence interval [CI] 1.11-1.75), human cytomegalovirus (OR = 2.25, 95% CI 1.14-4.43), human papillomavirus (HPV) (OR = 1.63, 95% CI 1.05-2.54), and John Cunningham virus (OR = 2.52, 95% CI 1.26-5.04). In subgroup analyses, HPV-16 infection was significantly associated with GC (OR = 2.42, 95% CI 1.00-5.83). Discussion This study demonstrated that hepatitis B virus, human cytomegalovirus, HPV, and John Cunningham virus were more prevalent in GC. However, the causal relationship between their infection and risk of GC remains inconclusive, and further investigations are required.
Izvorni podaci
- DOI
- 10.14309/ctg.0000000000000201
- PMID
- 32764207
- PMCID
- PMC7386361
- Provjereno
- 2026-07-26
Naslov i sažetak prevedeni su automatski i prijevod može sadržavati netačnosti ili neprecizne stručne izraze. Za sve detalje, citiranje i medicinsko tumačenje pregledajte originalnu englesku verziju članka. Ne donosite zdravstvene odluke samo na osnovu ovog prijevoda.
Pregledaj originalni članak na engleskom