Prevalencija osteoporoze i osteopenije kod muškaraca i žena u premenopauzi sa celijakijom: sistematski pregled.
Nutrition journal
Sažetak istraživanja
Pozadina Celijakija (CD) je poznata kao uzrok metaboličke osteopatije. Napredak neinvazivnih metoda kao što je denzitometrija kostiju pokazao je da je značajan omjer slučajeva CD-a suočen s oštećenom koštanom masom i takvi slučajevi su skloni prijelomima kostiju. Raznovrsnost niske mineralne gustine kostiju kod CD-a je vjerovatno zbog zanemarenih zbunjujućih faktora kao što su starost, menopauza i lijekovi.
Cilj našeg istraživanja bio je da se sistematski preispita učestalost osteoporoze i osteopenije među ženama i muškarcima u premenopauzi sa CD-om.
Metode Ovaj sistematski pregled je urađen na osnovu preferiranih stavki izvještavanja za smjernice za sistematske preglede (PRISMA). PubMed i Scopus i Cochran baze podataka pretražene su prema relevantnim naslovima medicinskih predmeta (MeSH) CD-a i mineralne gustine kostiju do 2018. godine. Prevalencija osteopenije i osteoporoze korištena je kao veličina efekta za metaanalizu. Cochrane Q (indeks p 2 predstavljen je kako bi se otkrila heterogenost.
Rezultati 54 prihvatljiva pregleda punog teksta su uključena i devetnaest odabranih za ekstrakciju podataka. Jedanaest članaka nije imalo naše kriterije uključivanja i zanemarili su zbunjujuće faktore kao što su starost i menopauza, a mi smo isključili; ekstrakcija podataka je obavljena u osam studija. Izvlačenje podataka je obavljeno u osam studija. Uključene su Indija, Mađarska i Poljska. Ukupna prevalencija osteoporoze iznosila je 14,4% [95%CI: 9-20,5%] (Cochrane Q = 7,889, p = 0,96, I 2 = 49,29%), a osteopenija je bila 39,6% = 84% [31,4%; 0,07, I 2 = 71,92%).
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Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review.
Background Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. The aim of our study was to systematically review the osteoporosis and osteopenia incidences among premenopausal females and males with CD.
Methods This systematic review was done based on preferred reporting items for systematic reviews (PRISMA) guidelines. PubMed and Scopus and Cochran databases were searched according to the relevant medical subject headings (MeSH) of CD and bone mineral density until 2018. Prevalence of osteopenia and osteoporosis were used as effect size for meta-analysis. Cochrane Q (p 2 index were presented to reveal the heterogeneity.
Results 54 eligible full text reviews were included and nineteen selected for data extraction. Eleven articles didn't have our inclusion criteria and had ignored confounding factors like age and menopause, and we excluded; data extraction was done in eight studies. A total of 563 premenopausal women and men who were from, UK, Brazil, India, Hungary, and Poland were included. The pooled prevalence of osteoporosis was 14.4% [95%CI: 9-20.5%] (Cochrane Q = 7.889, p = 0.96, I 2 = 49.29%), and osteopenia was 39.6% [31.1-48.8%] (Cochrane Q = 14.24, p = 0.07, I 2 = 71.92%), respectively.
Conclusion Our findings suggest that bone loss is more prevalent in celiac disease and can be associated with increased risk of fracture. However, but results are pooled prevalence and we need more case -control studies with more sample size and consideration of confounding factors.
Izvorni podaci
- DOI
- 10.1186/s12937-019-0434-6
- PMID
- 30732599
- PMCID
- PMC6504166
- Provjereno
- 2026-07-26
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