Vrijednost leukocitoze i povišenog C-reaktivnog proteina u predviđanju teškog korona virusa 2019. (COVID-19): sistematski pregled i meta-analiza.
Clinica chimica acta; international journal of clinical chemistry
Sažetak istraživanja
Pozadina Od decembra 2019. godine, korona virus 2019 (COVID-19) se proširio širom svijeta. Identifikacija loših prognostičkih faktora je od pomoći za stratifikaciju rizika. U ovoj meta-analizi istražili smo povezanost između teškog COVID-19 i promjene broja bijelih krvnih zrnaca (WBC), povećanja C-reaktivnog proteina (CRP) i groznice. Štaviše, cilj nam je bio da procenimo dijagnostičku tačnost leukocitoze i povišenja CRP.
Metode Izvršili smo sistematsko pretraživanje PubMed-a, EMBASE-a, Scopusa i Cochrane biblioteke do 20. aprila 2020. Izračunati su omjeri šansi (OR) i 95% intervali povjerenja (CI). Urađena je analiza osjetljivosti prema veličini studije (>200 ili 55 ili
Rezultati Odabrano je osamnaest studija sa 3278 pacijenata. Groznica, leukocitoza i povišen CRP su bili povezani sa lošim ishodima (OR (95% CI) 1,63 (1,06-2,51), 4,51-71 (1,06-2,51), 4,51-51) (4,97-28,8), respektivno, leukopenija je bila povezana sa boljom prognozom (OR 0,56, 95% CI 0,40-0,78). krivulje su bile 0,70 (0,64-0,76) odnosno 0,89 (0,80-0,99), respektivno.
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Value of leukocytosis and elevated C-reactive protein in predicting severe coronavirus 2019 (COVID-19): A systematic review and meta-analysis.
Background Since December 2019, coronavirus 2019 (COVID-19) has spread worldwide. Identifying poor prognostic factors is helpful for risk stratification. In this meta-analysis, we investigated the association between severe COVID-19 and a change in white blood cell (WBC) count, an elevation of C-reactive protein (CRP), and fever. Moreover, we aimed to evaluate the diagnostic accuracy of leukocytosis and an elevation of CRP.
Methods We performed a systematic search of PubMed, EMBASE, Scopus, and the Cochrane Library through April 20th, 2020. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. A sensitivity analysis was conducted according to the study size (>200 or 55 or
Results Eighteen studies with 3278 patients were selected. Fever, leukocytosis, and elevated CRP were associated with poor outcomes (OR (95% CI) 1.63 (1.06-2.51), 4.51 (2.53-8.04), and 11.97 (4.97-28.8), respectively). Leukopenia was associated with a better prognosis (OR 0.56, 95% CI 0.40-0.78). Sensitivity analyses showed similar tendencies. Meta-regression analysis for leukocytosis indicated that age, dyspnea, and hypertension contributed to heterogeneity. The pooled area under the leukocytosis and CRP curves were 0.70 (0.64-0.76) and 0.89 (0.80-0.99), respectively.
Conclusion In patients with COVID-19, fever, leukocytosis, and an elevated CRP were associated with severe outcomes. Leukocytosis and CRP on arrival may predict poor outcomes.
Izvorni podaci
- DOI
- 10.1016/j.cca.2020.06.008
- PMID
- 32533986
- PMCID
- PMC7832771
- Provjereno
- 2026-07-26
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