Disbioza crijeva u bolesnika s kroničnim bolom: sistematski pregled i meta-analiza.
Frontiers in immunology
Sažetak istraživanja
Uvod Nedavni dokazi podržavaju doprinos disbioze crijevne mikrobiote patofiziologiji reumatskih bolesti, neuropatskog bola i neurodegenerativnih poremećaja. Dvosmjerna komunikaciona mreža crijeva i mozga i pojava kronične boli uključuju doprinos autonomnog nervnog sistema i hipotalamus hipofize i nadbubrežne osovine. Ipak, trenutno razumijevanje povezanosti crijevne mikrobiote i kronične boli još uvijek nije jasno. Stoga je cilj ove studije sistematski procijeniti postojeće znanje o promjenama crijevne mikrobiote u stanjima kronične boli.
Metode Za ovaj sistematski pregled literature konsultovane su četiri baze podataka: PubMed, Web of Science, Scopus i Embase. Za procjenu rizika od pristrasnosti korištena je Newcastle-Ottawa skala. Protokol studije je prospektivno registrovan u Međunarodnom prospektivnom registru sistematskih pregleda (PROSPERO, CRD42023430115). Alfa-diverzitet, β-diverzitet i relativna brojnost na različitim taksonomskim nivoima sumirani su kvalitativno i kvantitativno ako je moguće.
Rezultati Početna pretraga baze podataka identifikovala je ukupno 3544 jedinstvene studije, od kojih je 21 studija na kraju uključena u sistematski pregled, a 11 u metaanalizu. Smanjenje alfa-diverziteta otkriveno je kod pacijenata sa hroničnim bolom u poređenju sa kontrolama za nekoliko metrika: posmatrane vrste (SMD= -0,201, 95% CI od -0,04 do -0,36, p=0,01), Shanonov indeks (SMD= -0,27, 95% CI od -0,431, p CI od -0,431, p. vrste Faecalibacterium prausnitzii i Odoribacter splanchnicus, kao i povećanje Eggerthelle spp., otkriveno je kod pacijenata s kroničnim bolom u odnosu na kontrolne skupine CRD42023430115.
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Gut dysbiosis in patients with chronic pain: a systematic review and meta-analysis.
Introduction Recent evidence supports the contribution of gut microbiota dysbiosis to the pathophysiology of rheumatic diseases, neuropathic pain, and neurodegenerative disorders. The bidirectional gut-brain communication network and the occurrence of chronic pain both involve contributions of the autonomic nervous system and the hypothalamic pituitary adrenal axis. Nevertheless, the current understanding of the association between gut microbiota and chronic pain is still not clear. Therefore, the aim of this study is to systematically evaluate the existing knowledge about gut microbiota alterations in chronic pain conditions.
Methods Four databases were consulted for this systematic literature review: PubMed, Web of Science, Scopus, and Embase. The Newcastle-Ottawa Scale was used to assess the risk of bias. The study protocol was prospectively registered at the International prospective register of systematic reviews (PROSPERO, CRD42023430115). Alpha-diversity, β-diversity, and relative abundance at different taxonomic levels were summarized qualitatively, and quantitatively if possible.
Results The initial database search identified a total of 3544 unique studies, of which 21 studies were eventually included in the systematic review and 11 in the meta-analysis. Decreases in alpha-diversity were revealed in chronic pain patients compared to controls for several metrics: observed species (SMD= -0.201, 95% CI from -0.04 to -0.36, p=0.01), Shannon index (SMD= -0.27, 95% CI from -0.11 to -0.43, p Faecalibacterium and Roseburia , and species of Faecalibacterium prausnitzii and Odoribacter splanchnicus , as well as an increase in Eggerthella spp., was revealed in chronic pain patients compared to controls. Discussion Indications for gut microbiota dysbiosis were revealed in chronic pain patients, with non-specific disease alterations of microbes. Systematic review registration https://www.crd.york.ac.uk/prospero/, identifier CRD42023430115.
Izvorni podaci
- DOI
- 10.3389/fimmu.2024.1342833
- PMID
- 38352865
- PMCID
- PMC10862364
- Provjereno
- 2026-07-26
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