Utjecaj nacionalnih karantina prvog talasa COVID-19 na perinatalne ishode: brzi pregled i meta-analiza.
BMC pregnancy and childbirth
Sažetak istraživanja
Pozadina Od pojave COVID-19, preventivne mjere javnog zdravlja, uključujući strategije izolacije, proglašene su u većini zemalja kako bi se kontrolirao prijenos virusa. Nedavne studije i anegdote izvijestile su o promjenama u prevalenciji perinatalnih ishoda tokom nacionalnih blokada zbog COVID-19.
Cilj ovog brzog pregleda bio je procijeniti utjecaj karantina COVID-19 na učestalost male porođajne težine (LBW), prijevremenog porođaja (PTB) i mrtvorođenih.
Metode Dva recenzenta su pretražila EMBASE, CORD-19, LitCovid (PubMed), Svjetsko istraživanje Svjetske zdravstvene organizacije o bolesti korona virusa (COVID-19) i MedRxiv za studije objavljene na engleskom jeziku od prvih izvještaja o COVID-19 do 17. jula 2021. Perinatalni ishodi od interesa uključivali su LBW (Rezultati pregledanih članaka 17 javnih članaka 1967 (14 kohortnih studija, 1 studija slučaja i 2 studije preseka uključivale su podatke iz Danske, UK, Irske, Nepala, Italije, Izraela, Bocvane, Saudijske Arabije, Austrije, Zimbabvea, Indije i Španije. izvještavajući o povećanju i smanjenju incidencije PTB-a, sa omjerom šansi [95% CI] u rasponu od 0,09 [0,01, 0,40] do 1,93 [0,76, 4,79] Tri studije su otkrile smanjenje stope LBW tokom blokade, od kojih je jedna bila statistički značajna, sa stopom od 1,17]. studije su ispitivale stope mrtvorođenosti, uključujući četiri studije koje su izvještavale o statistički značajnom povećanju stope mrtvorođenosti, s prilagođenim relativnim rizikom u rasponu od 1,46 [1,13, 1,89] do 3,9 [1,83, 12,0] Četrnaest studija je sadržavalo podatke koji su se mogli kombinovati u meta-analizi koja je upoređena s peritalnim mjerama značajan rizik od mrtvorođenosti sa RR = 1,33 [95% CI 1,04, 1,69] u poređenju sa periodom prije izolacije LBW, PTB i mrtvorođenost i dalje su nejasni. Velike studije su pokazale oprečne rezultate, izvještavajući i o povećanju i smanjenju u odabranim perinatalnim rezultatima Zaključavanje zbog COVID-19 predstavlja priliku za učenje i promjene kako bi se promoviralo smanjenje vodećih uzroka smrtnosti djece širom svijeta.
Prikaži originalni naslov i sažetak na engleskom
The impact of COVID-19 first wave national lockdowns on perinatal outcomes: a rapid review and meta-analysis.
Background Since the emergence of COVID-19, preventative public health measures, including lockdown strategies, were declared in most countries to control viral transmission. Recent studies and anecdotes have reported changes in the prevalence of perinatal outcomes during national COVID-19lockdowns.The objective of this rapid review was to evaluate the impact of COVID-19 lockdowns on the incidence of low birth weight (LBW), preterm birth (PTB), and stillbirth.
Methods Two reviewers searched EMBASE, CORD-19, LitCovid (PubMed), WHO Global research on corona virus disease (COVID-19), and MedRxiv for studies published in English from the first reports on COVID-19 until 17 July 2021. Perinatal outcomes of interest included LBW (
Results Of the 1967 screened articles, 17 publications met the inclusion criteria (14 cohort studies, 1 case control and 2 cross-sectional studies). Studies included data from Denmark, UK, Ireland, Nepal, Italy, Israel, Botswana, Australia, China, Netherlands, Saudi Arabia, Austria, Zimbabwe, India, and Spain. The total sample size ranged from 3399 to 1,599,547 pregnant women. Thirteen studies examined PTB with conflicting results, reporting both an increase and a decrease in PTB incidence, with odds ratios [95% CI] ranging from 0.09 [0.01, 0.40] to 1.93 [0.76, 4.79]. Three studies found a decrease in LBW rates during lockdowns, one of which was statistically significant, with a rate ratio of 3.77 [1.21, 11.75]. Ten studies examined stillbirth rates, including four studies reporting a statistically significant increase in stillbirth rates, with adjusted relative risk ranging from 1.46 [1.13, 1.89] to 3.9 [1.83, 12.0]. Fourteen studies contained data that could be combined in a meta-analysis comparing perinatal outcomes before and during lockdown. We found that lockdown measures were associated with a significant risk of stillbirth with RR = 1.33 [95% CI 1.04, 1.69] when compared to before lockdown period. However, lockdown measures were not associated with a significant risk of PTB, LBW and VLBW compared to prepandemic periods.
Conclusions This review provides clues about the severity of the indirect influence of COVID-19 lockdown implementation; however, the criteria that lead to unexpected changes in LBW, PTB, and stillbirth remains unclear. Large studies showed conflicting results, reporting both increases and decreases in selected perinatal outcomes. Pooled results show a significant association between lockdown measures and stillbirth rates, but not low birth weight rates. Further studies examining the differences in other countries' lockdowns and sociodemographic groups from low to middle-income countries are needed. Exploration of perinatal outcomes during COVID-19 lockdown poses an opportunity to learn from and make changes to promote the reduction of the leading causes of childhood mortality worldwide.
Izvorni podaci
- DOI
- 10.1186/s12884-021-04156-y
- PMID
- 34615505
- PMCID
- PMC8532086
- Provjereno
- 2026-07-26
Naslov i sažetak prevedeni su automatski i prijevod može sadržavati netačnosti ili neprecizne stručne izraze. Za sve detalje, citiranje i medicinsko tumačenje pregledajte originalnu englesku verziju članka. Ne donosite zdravstvene odluke samo na osnovu ovog prijevoda.
Pregledaj originalni članak na engleskom