Sistemski pregled i meta-analiza vodećih patogena koji uzrokuju neonatalnu sepsu u zemljama u razvoju.
BioMed research international
Sažetak istraživanja
Pozadina Neonatalna sepsa je jedan od najvećih problema javnog zdravlja na globalnom nivou, posebno u zemljama u razvoju. Klebsiella, Staphylococcus aureus, Coagulase-negative Staphylococcus i Escherichia coli česti su patogeni neonatalne sepse u zemljama u razvoju. Međutim, objedinjena procjena uobičajenih patogena koji uzrokuju neonatalnu sepsu u zemljama u razvoju još uvijek je nepoznata. Stoga je cilj ove studije izračunati zbirni udio vodećeg uzroka patogena neonatalne sepse u zemljama u razvoju.
Metode Strogo smo slijedili Preferirane stavke izvještavanja za sistemske preglede i smjernice za meta-analizu da bismo prijavili ovaj sistematski pregled i meta-analizu. PubMed, Cochrane Library, Web of Science, CINAHL, Science Direct i drugi pretraživači kao što su Google Scholar, Africa Journals Online i Hinari korišteni su za dobivanje studija koje se odnose na vodeći uzrok patogena neonatalne sepse u zemljama u razvoju. Pretraga je vršena od 1. oktobra do 30. decembra 2018. godine, uzimajući u obzir objavljenu i sivu literaturu. Studije su evaluirane na osnovu kontrolne liste smjernica PRISMA korištenjem njihovih naslova, sažetaka i punih tekstova. Studije su ekstrahovane korišćenjem Microsoft Excel tabela, a za analizu podataka korišćen je STATA softver verzije 14. Heterogenost između studija je provjerena na osnovu Cochranovog Q-testa i odgovarajućeg I 2 statističkog testa.
Rezultati Objedinjena prevalenca vodećeg uzroka patogena neonatalne sepse u zemljama u razvoju bili su Klebsiella (26,36%), Staphylococcus aureus (23,22%), Koagulaza-negativni Staphylococcus (23,22%) i Escherichia coli (15,30%). Uobičajeni patogeni su varirali u različitim regijama; na primjer, objedinjeni izolovani koagulazno negativni Staphylococcus bio je 25,98% u Africi, 16,62% u Aziji i 36,71% u Latinskoj Americi, a Klebsiella je bila 29,80% u Africi, 23,21% u Aziji i 22,00% u Latinskoj Americi. Takođe, Staphylococcus aureus je bio 27,87% u Africi i 18,28% u Aziji, a Escherichia coli je bio 22,97% u Aziji i 9,43% u Africi.
Zaključci Ova studija naglašava da su najčešći izolirani patogeni u zemljama u razvoju bili Klebsiella , Staphylococcus aureus , Coagulase-negative Staphylococcus , a patogeni Escherichia coli , Klebsiella i Staphylococcus aureus su bili pretežno visoki u azijskoj Africi i drugim zemljama Latinske Amerike. Istovremeno, koagulaza-negativni stafilokok bio je češći u Latinskoj Americi u poređenju sa drugim regionima. Escherichia coli je dominantnija u Aziji u odnosu na Afriku i Latinsku Ameriku.
Prikaži originalni naslov i sažetak na engleskom
A Systemic Review and Meta-analysis of the Leading Pathogens Causing Neonatal Sepsis in Developing Countries.
Background Neonatal sepsis is one of the major public health problems globally, particularly, in developing countries. Klebsiella , Staphylococcus aureus , Coagulase-negative Staphylococcus , and Escherichia coli are the common pathogens for neonatal sepsis in developing countries. However, the pooled estimate of common pathogens causing neonatal sepsis in developing countries is still unknown. Therefore, this study is aimed at computing the pooled proportion of the leading cause of pathogens for neonatal sepsis in developing countries.
Methods We strictly followed the Preferred Reporting Items for Systemic Reviews and Meta-analysis guidelines to report this systematic review and meta-analysis. PubMed, Cochrane Library, Web of Science, CINAHL, Science Direct, and other search engines such as Google Scholar, Africa Journals Online, and Hinari were used to obtain studies related to the leading cause of pathogens for neonatal sepsis in developing countries. The search was done from October 1 to December 30, 2018, by considering both published and gray literature. Studies were evaluated based on the PRISMA guideline checklist by using their titles, abstracts, and full texts. Studies were extracted using Microsoft Excel spreadsheets, and STATA software version 14 was used to analyze data. Heterogeneity between studies was checked based on Cochran's Q -test and the corresponding I 2 statistic test.
Results The pooled prevalence of the leading cause of pathogens of neonatal sepsis in developing countries were Klebsiella (26.36%), Staphylococcus aureus (23.22%), Coagulase-negative Staphylococcus (23.22%), and Escherichia coli (15.30%). Common pathogens were varied across regions; for instance, pooled isolated Coagulase-negative Staphylococcus was 25.98% in Africa, 16.62% in Asia, and 36.71% in Latin America, and Klebsiella was 29.80% in Africa, 23.21% in Asia, and 22.00% in Latin America. Also, Staphylococcus aureus was 27.87% in Africa and 18.28% in Asia, and Escherichia coli was 22.97% in Asia and 9.43% in Africa.
Conclusions This study highlights that the more prevalent common isolated pathogens in developing countries were Klebsiella , Staphylococcus aureus , Coagulase-negative Staphylococcus , and Escherichia coli , Klebsiella , and Staphylococcus aureus pathogens were predominantly high in Africa as compared to other Asian and Latin American countries. At the same time, Coagulase-negative Staphylococcus was more prevalent in Latin America compared to other regions. Escherichia coli is more dominant in Asia as compared to Africa and Latin America.
Izvorni podaci
- DOI
- 10.1155/2021/6626983
- PMID
- 34195273
- PMCID
- PMC8203353
- Provjereno
- 2026-07-26
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