Utjecaj nivoa vitamina D na infekciju COVID-19: sistematski pregled i meta-analiza.
Frontiers in public health
Sažetak istraživanja
Pozadina: Koronavirusna bolest (COVID-19) je respiratorni i sistemski poremećaj uzrokovan Teškim akutnim respiratornim sindromom Coronavirus 2 (SARS-CoV-2) ili novim koronavirusom (nCoV). Do danas, nema dokazanog kurativnog tretmana za ovaj virus; kao rezultat toga, prevencija ostaje najbolja strategija za borbu protiv infekcije koronavirusom (COVID-19). Predloženo je da nedostatak vitamina D (VDD) igra ulogu u infekciji koronavirusom (COVID-19). Međutim, ne postoje uvjerljivi dokazi o njegovom utjecaju na infekciju COVID-19. Stoga je ovaj pregled imao za cilj da sumira dostupne dokaze o povezanosti između nivoa vitamina D i rizika od infekcije COVID-19. Metode: Sistematsko pretraživanje literature u bazama podataka (PUBMED/MEDLINE, Cochrane/Wiley biblioteka, Scopus i SciELO) sprovedeno je od 15. maja 2020. do 20. decembra 2020. Studije koje su procjenjivale uticaj nivoa vitamina D na infekciju COVID-19/SARS-2 razmatrane su za pregled infekcije. Kvaliteti uključenih studija ocijenjeni su korištenjem JBI alata. Provedena je meta-analiza sa modelom slučajnih efekata i prijavljen je omjer šansi sa njihovim 95% CI. Ovaj sistematski pregled i metaanaliza se izvještavaju prema preferiranim stavkama izvještavanja za sistematski pregled i metaanalizu (PRISMA) smjernicama. Rezultati: Elektronska i dopunska pretraga ovog pregleda dala je 318 zapisa od kojih je samo 14 ispunjavalo kriterijume za uključivanje. Kvalitativna sinteza je pokazala da su osobe s nedostatkom vitamina D izložene većem riziku od infekcije COVID-19 u usporedbi s pacijentima koji imaju dovoljno vitamina D. Objedinjena analiza je pokazala da osobe s nedostatkom vitamina D imaju 80% veću vjerovatnoću da će dobiti infekciju COVID-19 u poređenju sa onima koji imaju dovoljan nivo vitamina D (OR = 1,80; 95%CI: 1,72, 1,88). Beggov test je također otkrio da nije bilo značajne pristranosti u objavljivanju između studija (P = 0,764). Analiza podgrupa otkrila je da je rizik od dobivanja infekcije COVID-19 bio relativno veći u dizajnu studije slučaj-kontrola (OR = 1,81). Zaključci: U zaključku, nizak nivo serumskog 25 (OH) vitamina-D je značajno povezan s većim rizikom od infekcije COVID-19. Ograničeni trenutno dostupni podaci sugeriraju da je dovoljan nivo vitamina D u serumu povezan sa značajno smanjenim rizikom od infekcije COVID-19.
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The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis.
Background: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV). To date, there is no proven curative treatment for this virus; as a result, prevention remains to be the best strategy to combat coronavirus infection (COVID-19). Vitamin D deficiency (VDD) has been proposed to play a role in coronavirus infection (COVID-19). However, there is no conclusive evidence on its impact on COVID-19 infection. Therefore, the present review aimed to summarize the available evidence regarding the association between Vitamin D levels and the risk of COVID-19 infection. Methods: A systematic literature search of databases (PUBMED/MEDLINE, Cochrane/Wiley library, Scopus, and SciELO) were conducted from May 15, 2020, to December 20, 2020. Studies that assessed the effect of vitamin D level on COVID-19/SARS-2 infection were considered for the review. The qualities of the included studies were evaluated using the JBI tools. Meta-analysis with a random-effects model was conducted and odds ratio with their 95%CI were reported. This systematic review and meta-analysis are reported according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline. Results: The electronic and supplementary searches for this review yielded 318 records from which, only 14 of them met the inclusion criteria. The qualitative synthesis indicated that vitamin D deficient individuals were at higher risk of COVID-19 infection as compared to vitamin D sufficient patients. The pooled analysis showed that individuals with Vitamin-D deficiency were 80% more likely to acquire COVID-19 infection as compared to those who have sufficient Vitamin D levels (OR = 1.80; 95%CI: 1.72, 1.88). Begg's test also revealed that there was no significant publication bias between the studies ( P = 0.764). The subgroup analysis revealed that the risk of acquiring COVID-19 infection was relatively higher in the case-control study design (OR = 1.81). Conclusions: In conclusion, low serum 25 (OH) Vitamin-D level was significantly associated with a higher risk of COVID-19 infection. The limited currently available data suggest that sufficient Vitamin D level in serum is associated with a significantly decreased risk of COVID-19 infection.
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- DOI
- 10.3389/fpubh.2021.624559
- PMID
- 33748066
- PMCID
- PMC7973108
- Provjereno
- 2026-07-26
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