Infekcija virusom Chikungunya u Indoneziji: sistematski pregled i evolucijska analiza.
BMC infectious diseases
Sažetak istraživanja
Istorijat Uprkos velikom broju slučajeva čikungunje u Indoneziji poslednjih godina, nedostaju sveobuhvatni epidemiološki podaci. Sistematski pregled je poduzet kako bi se osigurali podaci o incidenci, seroprevalenci anti-Chikungunya virusa (CHIKV) IgM i IgG antitijela, mortalitetu, genotipovima cirkulirajućeg CHIKV-a i slučajevima chikungunya vezanim za putovanja u zemlji. Osim toga, provedena je filogenetska i evolucijska analiza indonezijskog CHIKV-a.
Metode Sproveden je sistematski pregled kako bi se identifikovale prihvatljive studije od EMBASE, MEDLINE, PubMed i Web of Science od 16. oktobra 2017. Studije koje opisuju incidencu, seroprevalencu IgM i IgG, mortalitet, genotipove i chikungunya sistem povezan sa putovanjima su pregledani. Filogenetska i evolucijska stopa maksimalne vjerovatnoće procijenjena je korištenjem Randomized Axelerated Maximum Likelihood (RAxML), a Bayesian Markov lanac Monte Carlo (MCMC) metoda je identificirala vrijeme do najnovijih zajedničkih predaka (TMRCA) indonezijskog CHIKV-a. Sistematski pregled je registrovan u bazi podataka PROSPERO (CRD42017078205).
Rezultati Incidencija Chikungunya se kretala između 0,16-36,2 slučaja na 100.000 osoba godišnje. Sveukupno, srednja seroprevalencija anti-CHIKV IgM antitijela u scenarijima izbijanja i bez izbijanja bila je 13,3% (17,7 i 7,3% za događaje izbijanja i ne-izbijanja, respektivno). Srednja seroprevalencija IgG antitijela u okruženju izbijanja i izvan izbijanja bila je 18,5% (raspon 0,0-73,1%). Bilo je dostupno 130 indonezijskih CHIKV sekvenci, od kojih je 120 (92,3%) bilo azijskog genotipa, a 10 (7,7%) pripadalo je genotipu Istočne/Centralne/Južnoafričke (ECSA). ECSA genotip je prvi put izolovan u Indoneziji 2008. godine i kontinuirano se uzorkovao do 2011. Svi ECSA virusi uzorkovani u Indoneziji izgleda da su blisko povezani sa virusima koji su izazvali masovne epidemije u zemljama jugoistočne Azije tokom istog perioda. Masovne epidemije čikungunije u Indoneziji su prijavljene tokom 2009.-2010. sa ukupno 137.655 slučajeva. Naši prostorno-vremenski, filogenetski i evolucijski podaci sugeriraju da su ove epidemije vjerovatno povezane s uvođenjem ECSA genotipa CHIKV u Indoneziju.
Zaključci Iako nisu zabilježeni smrtni slučajevi, seroprevalencija anti-CHIKV IgM i IgG u indonežanskoj populaciji bila je relativno visoka posljednjih godina nakon ponovnog pojavljivanja početkom 2001. Postoji dovoljno dokaza koji ukazuju na to da je uvođenje ECSA u Indoneziju vjerovatno povezano s masivnim chikungunya epidemijama.
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Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis.
Background Despite the high number of chikungunya cases in Indonesia in recent years, comprehensive epidemiological data are lacking. The systematic review was undertaken to provide data on incidence, the seroprevalence of anti-Chikungunya virus (CHIKV) IgM and IgG antibodies, mortality, the genotypes of circulating CHIKV and travel-related cases of chikungunya in the country. In addition, a phylogenetic and evolutionary analysis of Indonesian CHIKV was conducted.
Methods A systematic review was conducted to identify eligible studies from EMBASE, MEDLINE, PubMed and Web of Science as of October 16th 2017. Studies describing the incidence, seroprevalence of IgM and IgG, mortality, genotypes and travel-associated chikungunya were systematically reviewed. The maximum likelihood phylogenetic and evolutionary rate was estimated using Randomized Axelerated Maximum Likelihood (RAxML), and the Bayesian Markov chain Monte Carlo (MCMC) method identified the Time to Most Recent Common Ancestors (TMRCA) of Indonesian CHIKV. The systematic review was registered in the PROSPERO database (CRD42017078205).
Results Chikungunya incidence ranged between 0.16-36.2 cases per 100,000 person-year. Overall, the median seroprevalence of anti-CHIKV IgM antibodies in both outbreak and non-outbreak scenarios was 13.3% (17.7 and 7.3% for outbreak and non-outbreak events, respectively). The median seroprevalence of IgG antibodies in both outbreak and non-outbreak settings was 18.5% (range 0.0-73.1%). There were 130 Indonesian CHIKV sequences available, of which 120 (92.3%) were of the Asian genotype and 10 (7.7%) belonged to the East/Central/South African (ECSA) genotype. The ECSA genotype was first isolated in Indonesia in 2008 and was continually sampled until 2011. All ECSA viruses sampled in Indonesia appear to be closely related to viruses that caused massive outbreaks in Southeast Asia countries during the same period. Massive nationwide chikungunya outbreaks in Indonesia were reported during 2009-2010 with a total of 137,655 cases. Our spatio-temporal, phylogenetic and evolutionary data suggest that these outbreaks were likely associated with the introduction of the ECSA genotype of CHIKV to Indonesia.
Conclusions Although no deaths have been recorded, the seroprevalence of anti-CHIKV IgM and IgG in the Indonesian population have been relatively high in recent years following re-emergence in early 2001. There is sufficient evidence to suggest that the introduction of ECSA into Indonesia was likely associated with massive chikungunya outbreaks during 2009-2010.
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- DOI
- 10.1186/s12879-019-3857-y
- PMID
- 30866835
- PMCID
- PMC6417237
- Provjereno
- 2026-07-26
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