Postoji li povezanost između neurodegenerativnih bolesti i parodontitisa? Sistematski pregled.
Frontiers in aging neuroscience
Sažetak istraživanja
Pozadina: Neurodegenerativne bolesti su grupa progresivnih poremećaja koji utiču na centralni nervni sistem (CNS) kao što su Alchajmer, Parkinson i multipla skleroza. Upala igra ključnu ulogu u nastanku i napredovanju ovih ozljeda. Parodontitis se smatra upalnom bolešću uzrokovanom oralnim biofilmom oko tkiva koja podržavaju zube, što dovodi do sistemskog i kroničnog upalnog stanja. Stoga je ovaj sistematski pregled imao za cilj traženje dokaza o povezanosti neurodegenerativnih poremećaja i parodontitisa. Metode: Ovaj sistematski pregled je registrovan u Međunarodnom prospektivnom registru sistematskih pregleda (PROSPERO) pod šifrom CRD 42016038327. Strategija pretraživanja je izvršena u tri elektronske baze podataka i jednom sivom literaturnom izvoru-PubMed, Scopus, Web of Science i OpenGrey, zasnovano na PECO akronimu u humanim bolestima koji je bio akronim neurodegenerativnih istraživanja (eng. (E) ili odsutan (C) da bi se uočila povezanost s parodontitisom (O). Kontrolna lista Fowkesa i Fultona korištena je za kritičku procjenu metodološkog kvaliteta i rizika od pristrasnosti pojedinačnih studija. Kvalitet dokaza je ocijenjen ocjenom ocjenjivanja, razvoja i evaluacije preporuka (GRADE). Rezultati: Od 534 pronađena članka, 12 je uključeno, od kojih je osam bilo u kontroli slučajeva, tri su bila poprečnog presjeka, a jedan je bio kohorta, što je dalo ukupno 3.460 učesnika. Sve uključene studije izvijestile su o povezanosti između nekih neurodegenerativnih bolesti i parodontitisa i predstavljale nizak rizik od pristranosti. Prema GRADE pristupu, nivo dokaza o dubini džepa sondiranja smatran je veoma niskim zbog značajne heterogenosti u nepreciznosti i nedosljednosti nadogradnje studija. Zaključci: Iako su sve uključene studije u ovom pregledu izvijestile o povezanosti neurodegenerativnih bolesti i parodontitisa, nivo dokaza je klasifikovan kao vrlo nizak, što sugerira oprezno tumačenje rezultata.
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Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review.
Background: Neurodegenerative diseases are a group of progressive disorders that affect the central nervous system (CNS) such as Alzheimer, Parkinson, and multiple sclerosis. Inflammation plays a critical role in the onset and progression of these injuries. Periodontitis is considered an inflammatory disease caused by oral biofilms around the tooth-supporting tissues, leading to a systemic and chronic inflammatory condition. Thus, this systematic review aimed to search for evidence in the association between neurodegenerative disorders and periodontitis. Methods: This systematic review was registered at International Prospective Register of Systematic Reviews (PROSPERO) under the code CRD 42016038327. The search strategy was performed in three electronic databases and one gray literature source-PubMed, Scopus, Web of Science, and OpenGrey, based on the PECO acronym: observational studies in humans (P) in which a neurodegenerative disease was present (E) or absent (C) to observe an association with periodontitis (O). The Fowkes and Fulton checklist was used to critically appraise the methodological quality and the risk of bias of individual studies. The quality of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: From 534 articles found, 12 were included, of which eight were case-control, three were cross-sectional, and one was a cohort, giving a total of 3,460 participants. All the included studies reported an association between some neurodegenerative diseases and periodontitis and presented a low risk of bias. According to the GRADE approach, the level of evidence of probing pocket depth was considered very low due to the significant heterogeneity across the studies' upgrading imprecision and inconsistency. Conclusions: Although all the included studies in this review reported an association between neurodegenerative diseases and periodontitis, the level of evidence was classified to be very low, which suggests a cautious interpretation of the results.
Izvorni podaci
- DOI
- 10.3389/fnagi.2021.651437
- PMID
- 34108875
- PMCID
- PMC8180549
- Provjereno
- 2026-07-26
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